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Mech Dev March 1, 2003; 120 (3): 337-48.

Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm development.

Clements D , Cameleyre I , Woodland HR .

We have used antisense morpholino oligos to establish the developmental roles of three Xsox17 proteins in Xenopus development (Xsox17alpha(1), alpha(2) and beta). We show that their synthesis can be inhibited with modest amounts of oligo. The inhibition of each individually produces defects in late midgut development. Loss of activity of the Xsox17alpha proteins additionally inhibits hindgut formation, and inhibiting Xsox17alpha(1) disrupts foregut development with variable penetrance. When all Xsox17 activity is inhibited cell movements are halted during late gastrulation and the transcription of several endodermally expressed genes is reduced. Thus the Xsox17 proteins have redundant roles in early development of the endoderm and partly distinct roles during later organogenesis.

PubMed ID: 12591603
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: a2m eomes foxa2 gata5 kcnt1 myc myod1 nr3c1 odc1 otx2 pc.1 sox17a sox17b.1 sox17b.2 tbx2
Antibodies: Sox17a Ab1
Morpholinos: sox17a MO1 sox17a MO2 sox17a MO3 sox17a MO4 sox17b.1 MO1

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