Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Int J Mol Sci
2020 Nov 14;2122:. doi: 10.3390/ijms21228593.
Show Gene links
Show Anatomy links
Comparative Studies of Polysialic Acids Derived from Five Different Vertebrate Brains.
Yang Y
,
Murai R
,
Takahashi Y
,
Mori A
,
Hane M
,
Kitajima K
,
Sato C
.
???displayArticle.abstract???
Polysialic acid (polySia/PSA) is a linear homopolymer of sialic acid (Sia) that primarily modifies the neural cell adhesion molecule (NCAM) in mammalian brains. PolySia-NCAM not only displays an anti-adhesive function due to the hydration effect, but also possesses a molecule-retaining function via a direct binding to neurologically active molecules. The quality and quantity of polySia determine the function of polySia-NCAM and are considered to be profoundly related to the maintenance of normal brain functions. In this study, to compare the structures of polySia-NCAM in brains of five different vertebrates (mammals, birds, reptiles, amphibians, and fish), we adopted newly developed combinational methods for the analyses. The results revealed that the structural features of polySia considerably varied among different species. Interestingly, mice, as a mammal, possess eminently distinct types of polySia, in both quality and quantity, compared with those possessed by other animals. Thus, the mouse polySia is of larger quantities, of longer and more diverse chain lengths, and of a larger molecular size with higher negative charge, compared with polySia of other species. These properties might enable more advanced brain function. Additionally, it is suggested that the polySia/Sia ratio, which likely reflects the complexity of brain function, can be used as a new promising index to evaluate the intelligence of different vertebrate brains.
Abe,
Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain.
2019, Pubmed
Abe,
Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain.
2019,
Pubmed
Abe,
Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex.
2017,
Pubmed
Angata,
Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior.
2004,
Pubmed
Angata,
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
2002,
Pubmed
Angata,
Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.
1998,
Pubmed
Arai,
Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.
2006,
Pubmed
BARRY,
Colominic acid, a substance of bacterial origin related to sialic acid.
1957,
Pubmed
Barbeau,
Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains.
1995,
Pubmed
Bonfanti,
Mapping of the distribution of polysialylated neural cell adhesion molecule throughout the central nervous system of the adult rat: an immunohistochemical study.
1992,
Pubmed
Cremer,
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.
1994,
Pubmed
Curreli,
Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.
2007,
Pubmed
Finne,
Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain.
1982,
Pubmed
Fuster,
Frontal lobe and cognitive development.
2002,
Pubmed
Galuska,
Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain.
2010,
Pubmed
Galuska,
Mass spectrometric fragmentation analysis of oligosialic and polysialic acids.
2010,
Pubmed
Gascon,
Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons.
2007,
Pubmed
Gattenlöhner,
Specific detection of CD56 (NCAM) isoforms for the identification of aggressive malignant neoplasms with progressive development.
2009,
Pubmed
Gilabert-Juan,
Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients.
2012,
Pubmed
Hallenbeck,
Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units.
1987,
Pubmed
Hane,
Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF.
2015,
Pubmed
Inoue,
Isolation of a novel glycoprotein from the eggs of rainbow trout: occurrence of disialosyl groups on all carbohydrate chains.
1978,
Pubmed
Isomura,
Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia.
2011,
Pubmed
Jerison,
Animal intelligence as encephalization.
1985,
Pubmed
Kanato,
Direct binding of polysialic acid to a brain-derived neurotrophic factor depends on the degree of polymerization.
2008,
Pubmed
Kröcher,
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
2015,
Pubmed
Mori,
Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains.
2020,
Pubmed
Mori,
Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.
2017,
Pubmed
Nagae,
Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid.
2013,
Pubmed
Ono,
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid.
2012,
Pubmed
Owen,
Schizophrenia.
2016,
Pubmed
Paton,
The primate amygdala represents the positive and negative value of visual stimuli during learning.
2006,
Pubmed
Pilbeam,
Size and scaling in human evolution.
1974,
Pubmed
Roth,
Evolution of the brain and intelligence.
2005,
Pubmed
Rutishauser,
Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.
2008,
Pubmed
SCOVILLE,
Loss of recent memory after bilateral hippocampal lesions.
1957,
Pubmed
Sato,
Disialic, oligosialic and polysialic acids: distribution, functions and related disease.
2013,
Pubmed
Sato,
Mental disorders and an acidic glycan-from the perspective of polysialic acid (PSA/polySia) and the synthesizing enzyme, ST8SIA2.
2018,
Pubmed
Sato,
Sialic Acids in Neurology.
2019,
Pubmed
Sato,
Frequent occurrence of pre-existing alpha 2-->8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins. Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo-, and poly-Sia antibodies specific for defined chain lengths.
2000,
Pubmed
Sato,
Measurement of glycan-based interactions by frontal affinity chromatography and surface plasmon resonance.
2010,
Pubmed
Sato,
Characterization of the antigenic specificity of four different anti-(alpha 2-->8-linked polysialic acid) antibodies using lipid-conjugated oligo/polysialic acids.
1995,
Pubmed
Sato,
Fluorescent-assisted detection of oligosialyl units in glycoconjugates.
1999,
Pubmed
Sato,
Development of a highly sensitive chemical method for detecting alpha2-->8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane.
1998,
Pubmed
Seki,
Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat.
1993,
Pubmed
Seki,
Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system.
1993,
Pubmed
Senkov,
Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm.
2006,
Pubmed
Senkov,
PSA-NCAM: synaptic functions mediated by its interactions with proteoglycans and glutamate receptors.
2012,
Pubmed
Williams,
Primate encephalization and intelligence.
2002,
Pubmed
Yabe,
Polysialic acid in human milk. CD36 is a new member of mammalian polysialic acid-containing glycoprotein.
2003,
Pubmed
Yang,
Role of charge and hydration in effects of polysialic acid on molecular interactions on and between cell membranes.
1994,
Pubmed
Zuber,
Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAM in adult rat brain.
1992,
Pubmed
