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XB-ART-5810
Proc Natl Acad Sci U S A February 18, 2003; 100 (4): 1769-74.

Tadpole skin dies autonomously in response to thyroid hormone at metamorphosis.



Abstract
Transgenic tadpoles that express a dominant negative thyroid hormone (TH) receptor specifically in their skin undergo normal metamorphosis, with one exception: they retain a larval epidermis over the developing adult epithelium. TH-induced death of the tadpole epidermis is inhibited by the dominant negative TH receptor whereas the TH-induced response of the neighboring fibroblasts and the cells that form the adult skin occur normally. Therefore death of the tadpole skin is a direct and cell autonomous target of TH, and its protection has no detectable influence on TH-induced changes of other cell types.

PubMed ID: 12560472
PMC ID: PMC149908
Article link: Proc Natl Acad Sci U S A

Genes referenced: casp3.2 dan4l krt12.5 krt62 krt78.6 thdl20


Article Images: [+] show captions
References [+] :
Berry, The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs. 1998, Pubmed, Xenbase


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