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Commun Biol January 1, 2021; 4 (1): 1158.
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The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos.

Massé K , Bhamra S , Paroissin C , Maneta-Peyret L , Boué-Grabot E , Jones EA .

The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major site of enpp expression and now demonstrate an unsuspected role for the conserved vertebrate enpp4 protein during kidney formation in Xenopus. Enpp4 over-expression results in ectopic renal tissues and, on rare occasion, complete mini-duplication of the entire kidney. Enpp4 is required and sufficient for pronephric markers expression and regulates the expression of RA, Notch and Wnt pathway members. Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P. Finally, we propose a novel and non-catalytic mechanism by which lipidic signalling regulates nephrogenesis.

PubMed ID: 34620987
PMC ID: PMC8497618
Article link: Commun Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: clcnkb enpp4 gata3 lhx1 myh4 myod1 nkx6-1 nphs1 pax8 s1pr5 slc12a1 slc5a1.1 tbxt wt1
GO keywords: kidney development [+]
Antibodies: Kidney Ab1 Kidney Ab2

Article Images: [+] show captions