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XB-ART-588
J Biol Chem May 5, 2006; 281 (18): 12986-93.

The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.

Cruciat CM , Hassler C , Niehrs C .


Abstract
Kremen1 and 2 (Krm1/2) are coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/beta-catenin signaling, and play a role in head induction during early Xenopus development. In a proteomic approach we identified Erlectin, a novel protein that interacts with Krm2. Erlectin (XTP3-B) is member of a protein family containing mannose 6-phosphate receptor homology (MRH-, or PRKCSH-) domains implicated in N-glycan binding. Like other members of the MRH family, Erlectin is a luminal resident protein of the endoplasmic reticulum. It contains two MRH domains, of which one is essential for Krm2 binding, and this interaction is abolished by Krm2 deglycosylation. The overexpression of Erlectin inhibits transport of Krm2 to the cell surface. Analysis of its embryonic expression pattern in Xenopus reveals that Erlectin is member of the endoplasmic reticulum synexpression group. Erlectin morpholino antisense injection leads to head and axial defects during organogenesis stages in Xenopus embryos. The results indicate that Erlectin functions in N-glycan recognition in the endoplasmic reticulum, suggesting that it may regulate glycoprotein traffic.

PubMed ID: 16531414
Article link: J Biol Chem

Genes referenced: ag1 ctnnb1 dkk1 dkk3 eea1 egr2 erlec1 foxg1 isyna1 kdelr2 kremen1 kremen2 lrp6 myc preb prkcsh sec61a1 sf1 tgoln2 wnt1
GO keywords: canonical Wnt signaling pathway
Morpholinos: erlec1 MO1 erlec1 MO2

Disease Ontology terms: mucolipidosis III alpha/beta
OMIMs: MUCOLIPIDOSIS III GAMMA

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