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XB-ART-6084
Mech Dev December 1, 2002; 119 (2): 177-90.

Xolloid-related: a novel BMP1/Tolloid-related metalloprotease is expressed during early Xenopus development.

Dale L , Evans W , Goodman SA .


Abstract
We have identified a novel Tolloid-like metalloprotease, called Xolloid-related (Xlr), that is expressed during early Xenopus development. Transcripts for xlr are localized to the marginal zone of mid-gastrulae and are most abundant in ventral and lateral sectors. At neurula stages xlr is strongly expressed around the blastopore and in the pharyngeal endoderm, and more weakly expressed throughout the ventral half of the embryo. Transcripts are detected in the nervous system, particularly the hindbrain and spinal cord, and tailbud of tailbud stage embryos, with weaker expression in the anterior nervous system, otic vesicle, heart, and pronephric duct. Transcription of xlr is increased by BMP4 and decreased by Noggin and tBR, indicating that xlr is regulated by BMP signalling. Injection of xlr mRNA inhibits dorsoanterior development and the dorsal axis inducing ability of coinjected chordin, but not noggin or tBR, mRNA. Xlr conditioned media cleaves Chordin in vitro, indicating that this protease may regulate the availability of Chordin in vivo.

PubMed ID: 12464431
Article link: Mech Dev

Genes referenced: bmp1 bmp4 chrd.1 cnot1 egr2 en2 foxg1 myf5 nog not otx2 tll1 tll2 wnt8a


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