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XB-ART-6121
Dev Dyn December 1, 2002; 225 (4): 536-43.

Xath5 regulates neurogenesis in the Xenopus olfactory placode.

Burns CJ , Vetter ML .


Abstract
Helix-loop-helix (HLH) genes function as important regulators of neurogenesis in both the peripheral and central nervous systems. The olfactory system is an ideal tissue in which to study the role of these genes in regulating the acquisition of neuronal cell fate, particularly that of the olfactory receptor neuron (ORN). Here we describe the expression of several basic HLH (bHLH) and repeat HLH (rHLH) factors during olfactory placode development in Xenopus laevis. Our work reveals that a combination of both bHLH and rHLH genes are sequentially expressed within the nascent olfactory placode during normal development. Moreover, overexpression of the bHLH factor, Xenopus atonal homologue 5 (Xath5), promotes olfactory neural fate independent of cellular proliferation within a restricted domain at the anterior of the embryo. Collectively, our data argue that HLH genes are expressed in a cascade during olfactory placode development and that the activity of an atonal homologue, Xath5, can promote ORN fate but only in the appropriate developmental context.

PubMed ID: 12454929
Article link: Dev Dyn
Grant support: [+]
Genes referenced: atoh7 btg3 ebf2 ebf3 elavl1 gal.2 h3-3a neurod1 neurod4 neurog2 omp tubb2b


Article Images: [+] show captions


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