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XB-ART-6328
Proc Natl Acad Sci U S A. November 12, 2002; 99 (23): 14855-60.

Potentiation of serum response factor activity by a family of myocardin-related transcription factors.

Wang DZ , Li S , Hockemeyer D , Sutherland L , Wang Z , Schratt G , Richardson JA , Nordheim A , Olson EN .


Abstract
Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.

PubMed ID: 12397177
PMC ID: PMC137508
Article link: Proc Natl Acad Sci U S A.

Genes referenced: acin1 apcs hnrnpu mkl1 myocd pias1 srf
Antibodies referenced:

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