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XB-ART-6384
Mech Dev November 1, 2002; 119 (1): 35-44.

XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis.



Abstract
The interaction between early proneural genes and lateral inhibition determines the number of primary neurons. The mechanism for regulating the size of the proneural domain, however, has not been clarified. We show here that inhibition of the function of XETOR in Xenopus, a homolog of human oncoprotein ETO/MTG8, leads to a neurogenic phenotype of expanded proneural domain without alteration in the density of primary neurons. This result suggests that XETOR is a prerequisite for regulating the size of the proneural domain. We further show that such a regulation is accomplished by establishing a negative feedback loop between XETOR and proneural genes except Xngnr-1, as well as by antagonism between XETOR and lateral inhibition.

PubMed ID: 12385752
Article link: Mech Dev

Genes referenced: ascl2 cbfa2t2 dll1 hes5.1 myt1 neurod1 neurod4 neurog2 nrarp runx1 sox3 tubb2b
GO keywords: nervous system development
Morpholinos: cbfa2t2 MO1


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