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Nature October 3, 2002; 419 (6906): 475-80.

Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases.

Sin WC , Haas K , Ruthazer ES , Cline HT .

Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton. Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.

PubMed ID: 12368855
Article link: Nature
Grant support: [+]
Genes referenced: actl6a akt1 cdc42 rac1 rho rho.2 rhoa

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