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XB-ART-6463
J Comp Neurol October 28, 2002; 452 (4): 381-91.

Expression of voltage-dependent potassium channels in the developing visual system of Xenopus laevis.

Pollock NS , Ferguson SC , McFarlane S .


Abstract
Accumulating evidence suggests that voltage-dependent potassium (Kv) channels have important and varied roles in the development of neuronal and non-neuronal cell types. They have been implicated in processes such as proliferation, cell adhesion, migration, neurite outgrowth, and axon guidance. In this study, we used antibodies against several electrically active Kv channel alpha-subunits (Kv1-4) to describe the spatial and temporal expression patterns of Kv channel subunits in Xenopus laevis retinal ganglion cell (RGC) somata, axons, and growth cones. We found that RGCs express Kv1.3-, Kv1.5-, Kv3.4-, and Kv4.2-like subunits. Each subunit displayed unique cellular and subcellular distributions. Moreover, the expression patterns changed considerably over the major period of Xenopus retinal cell genesis and differentiation. Weak or no immunoreactivity was observed with antibodies against Kv1.1, Kv1.2, Kv1.4, Kv1.6, and Kv3.2 subunits in RGCs or other retinal cell types. In support of our previous pharmacologic evidence implicating Kv channels in RGC axon outgrowth, we found that Kv1.5-, Kv3.4-, and Kv4.2-like proteins, but not Kv1.3-like subunits, are abundantly expressed in RGC growth cones.

PubMed ID: 12355420
Article link: J Comp Neurol

Genes referenced: actb actl6a isl1 kcna1 kcna3 kcna4 kcna5 kcnc4 kcnd2 kcnd3 slc12a3 zic1
Antibodies: Glia Ab2 Isl1/2 Ab1 Kcna1 Ab1 Kcna2 Ab1 Kcna3 Ab1 Kcna4 Ab1 Kcna5 Ab2 Kcna6 Ab1 Kcnc2 Ab1 Kcnc4 Ab1 Kcnd2 Ab2 Kcnd3 Ab1


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