FEBS Lett 2002 Jul 31;5241-3:116-22. doi: 10.1016/s0014-5793(02)03014-4.

Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors.

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Cone arrestin (CAR) is a novel member of the arrestin superfamily expressed in retinal cone photoreceptors and the pineal gland. To understand the regulatory mechanisms controlling its cone- and pineal-specific expression, and to facilitate further functional studies using gene knockout approaches, we characterized the genomic organization and the 5'-flanking region of the mouse CAR (mCAR) gene. The mCAR gene is comprised of 17 exons and 16 introns, encoding five alternatively spliced transcripts. A 215-bp proximal promoter fragment containing a TATA box, an Sp1 site and four cone-rod homeobox-binding sites is sufficient to direct expression in cultured retinoblastoma cells and in cone photoreceptors and the pineal gland in transgenic Xenopus laevis.

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Species referenced: Xenopus laevis
Genes referenced: arrb1 arrb2 sp1