Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.
PubMed ID: 12118257
PMC ID: PMC2887346
Article link: Nat Neurosci.
Grant support: AA12958 NIAAA NIH HHS , DA09618 NIDA NIH HHS , NS35047 NINDS NIH HHS , R01 AA012958-01 NIAAA NIH HHS , R01 AA012958-02 NIAAA NIH HHS , R01 DA009618-04 NIDA NIH HHS , R01 DA009618-05A2 NIDA NIH HHS , R01 AA012958 NIAAA NIH HHS , R01 DA009618 NIDA NIH HHS