Xenbase is experiencing difficulties due to technical problems with the University of Calgary IT infrastructure and may go temporarily offline.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Nat Neurosci. August 1, 2002; 5 (8): 721-2.

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Sundstrom-Poromaa I , Smith DH , Gong QH , Sabado TN , Li X , Light A , Wiedmann M , Williams K , Smith SS .

Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.

PubMed ID: 12118257
PMC ID: PMC2887346
Article link: Nat Neurosci.
Grant support: AA12958 NIAAA NIH HHS , DA09618 NIDA NIH HHS , NS35047 NINDS NIH HHS , R01 AA012958-01 NIAAA NIH HHS , R01 AA012958-02 NIAAA NIH HHS , R01 DA009618-04 NIDA NIH HHS , R01 DA009618-05A2 NIDA NIH HHS , R01 AA012958 NIAAA NIH HHS , R01 DA009618 NIDA NIH HHS

My Xenbase: [ Log-in / Register ]
version: [3.11.2]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556