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XB-ART-6912
Nature July 4, 2002; 418 (6893): 37-8.

Conserved function for embryonic nodal cilia.

Essner JJ , Vogan KJ , Wagner MK , Tabin CJ , Yost HJ , Brueckner M .


Abstract
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

PubMed ID: 12097899
Article link: Nature

Genes referenced: nodal nodal1

References :
Stern, Embryology: fluid flow and broken symmetry. 2002, Pubmed, Xenbase


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