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EMBO Rep
2002 Jun 01;36:551-6. doi: 10.1093/embo-reports/kvf111.
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Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1.
Peter M
,
Le Peuch C
,
Labbé JC
,
Meyer AN
,
Donoghue DJ
,
Dorée M
.
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At the G(2)/M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin-B-cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly before G(2)/M in the nucleus, it has been proposed that this induces cyclin-B1-cdc2 kinase activation. We demonstrate that cyclin B1 phosphorylation has another essential function in vivo: it is required for cdc25c and MPF activation, which does not require nuclear accumulation of cyclin B1, and occurs in the cytoplasm.
Abrieu,
The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs.
1998, Pubmed,
Xenbase
Abrieu,
The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs.
1998,
Pubmed
,
Xenbase
Blangy,
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
1995,
Pubmed
,
Xenbase
Borgne,
Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition.
1999,
Pubmed
,
Xenbase
Brandeis,
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
1998,
Pubmed
Dabauvalle,
Role of nuclear material in the early cell cycle of Xenopus embryos.
1988,
Pubmed
,
Xenbase
Dorée,
From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?
2002,
Pubmed
Fisher,
Germinal vesicle material is dispensable for oscillations in cdc2 and MAP kinase activities, cyclin B degradation and synthesis during meiosis in Xenopus oocytes.
1998,
Pubmed
,
Xenbase
Galaktionov,
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.
1991,
Pubmed
Gautier,
Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation.
1991,
Pubmed
,
Xenbase
Gautier,
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.
1991,
Pubmed
,
Xenbase
Hagting,
Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal.
1999,
Pubmed
Hagting,
MPF localization is controlled by nuclear export.
1998,
Pubmed
Hochegger,
New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation.
2001,
Pubmed
,
Xenbase
Hoffmann,
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
1993,
Pubmed
,
Xenbase
Izumi,
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.
1991,
Pubmed
,
Xenbase
Jessus,
Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B.
1992,
Pubmed
,
Xenbase
King,
Mitosis in transition.
1994,
Pubmed
Kobayashi,
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.
1991,
Pubmed
,
Xenbase
Kumagai,
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.
1996,
Pubmed
,
Xenbase
Labbé,
MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.
1989,
Pubmed
Labbé,
M phase-specific cdc2 kinase: preparation from starfish oocytes and properties.
1991,
Pubmed
,
Xenbase
Lee,
An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts.
1996,
Pubmed
,
Xenbase
Li,
Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation.
1995,
Pubmed
,
Xenbase
Li,
Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation.
1997,
Pubmed
,
Xenbase
Masui,
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
1971,
Pubmed
Meijer,
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.
1989,
Pubmed
Mueller,
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.
1995,
Pubmed
,
Xenbase
Murakami,
Analysis of the early embryonic cell cycles of Xenopus; regulation of cell cycle length by Xe-wee1 and Mos.
1998,
Pubmed
,
Xenbase
Nakajo,
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.
2000,
Pubmed
,
Xenbase
Nurse,
Universal control mechanism regulating onset of M-phase.
1990,
Pubmed
Peter,
The APC is dispensable for first meiotic anaphase in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Peter,
In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase.
1990,
Pubmed
Pines,
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.
1989,
Pubmed
Qian,
The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.
2001,
Pubmed
,
Xenbase
Sluder,
The coordination of centrosome reproduction with nuclear events during the cell cycle.
2000,
Pubmed
Solomon,
Cyclin activation of p34cdc2.
1990,
Pubmed
,
Xenbase
Takizawa,
Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.
2000,
Pubmed
,
Xenbase
Toyoshima-Morimoto,
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
2001,
Pubmed
,
Xenbase
Yang,
All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.
1999,
Pubmed
Zheng,
Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25.
1993,
Pubmed
,
Xenbase
