Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-7253
Dev Biol. May 1, 2002; 245 (1): 136-44.

Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus.

Luo T , Matsuo-Takasaki M , Thomas ML , Weeks DL , Sargent TD .


Abstract
Expression of the Xenopus homolog of the mammalian transcription factor AP-2alpha (XAP-2) is activated throughout the animal hemisphere shortly after the midblastula transition, and becomes restricted to prospective epidermis by the end of gastrulation, under the control of BMP signal modulation. Elevated expression in the future neural crest region begins at this time. Ectopic expression of XAP-2 can restore transcription of epidermal genes in neuralized ectoderm, both in ectodermal explants and in the intact embryo. Likewise, loss of XAP-2 function, accomplished by injection of antisense oligonucleotides or by overexpression of antimorphic XAP-2 derivatives, leads to loss of epidermal and gain of neural gene expression. These treatments also result in gastrulation failure. Thus, AP-2 is a critical regulator of ectodermal determination that is required for normal epidermal development and morphogenesis in the frog embryo.

PubMed ID: 11969261
Article link: Dev Biol.
Grant support: HL 42252 NHLBI NIH HHS , HL 42252 NHLBI NIH HHS , HL 42252 NHLBI NIH HHS , HL 42252 NHLBI NIH HHS , HL 42252 NHLBI NIH HHS , HL 42252 NHLBI NIH HHS

Genes referenced: bmp4 chrd dlx3 dlx5 klf6 msx1 tfap2a xk81a1 zic1
Antibodies referenced:
Article Images: [+] show captions

My Xenbase: [ Log-in / Register ]
version: [3.2.2]


Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556