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XB-ART-7355
Genes Dev April 1, 2002; 16 (7): 820-35.

The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling.

Ring C , Ogata S , Meek L , Song J , Ohta T , Miyazono K , Cho KW .


Abstract
We investigated the regulation of the activin/nodal-inducible distal element (DE) of the Xenopus goosecoid (gsc) promoter. On the basis of its interaction with the DE, we isolated a Xenopus homolog of the human Williams-Beuren syndrome critical region 11 (XWBSCR11), and further, show that it interacts with pathway-specific Smad2 and Smad3 in a ligand-dependent manner. Interestingly, we also find that XWBSCR11 functions cooperatively with FoxH1 (Fast-1) to stimulate DE-dependent transcription. We propose a mechanism in which FoxH1 functions together with Smads as a cofactor for the recruitment of transcription factors like XWBSCR11 in the process of activin/nodal-mediated gsc-specific induction. This mechanism provides considerable opportunities for modulation of transcription across a variety of activin/nodal-inducible genes, increasing diversity in promoter selection, thus leading to the differential induction of activin/nodal target genes.

PubMed ID: 11937490
PMC ID: PMC186325
Article link: Genes Dev
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: foxh1 foxh1.2 gnao1 gsc gtf2ird1 mix1 mixer nodal nodal1 smad2 smad3
Morpholinos: foxh1 MO1 gtf2ird1 MO1


Article Images: [+] show captions
References [+] :
Asashima, Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor). 2019, Pubmed, Xenbase