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XB-ART-7505
Nat Struct Biol 2002 Apr 01;94:263-7. doi: 10.1038/nsb776.
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Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes.

Horn PJ , Carruthers LM , Logie C , Hill DA , Solomon MJ , Wade PA , Imbalzano AN , Hansen JC , Peterson CL .


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Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle control. We find that the remodeling activities of the ySWI/SNF, hSWI/SNF, xMi-2 and xACF complexes are nearly abolished by incorporation of linker histones into nucleosomal array substrates. Much of this inhibition is independent of linker histone-induced folding of the arrays. We also find that phosphorylation of the linker histone by Cdc2/Cyclin B kinase can rescue remodeling by ySWI/SNF. These results suggest that linker histones exert a global, genome-wide control over remodeling activities, implicating a new, obligatory coupling between linker histone kinases and ATP-dependent remodeling enzymes.

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Species referenced: Xenopus laevis
Genes referenced: ccnb1.2 cdk1