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EMBO J March 1, 2002; 21 (5): 976-85.

The planar polarity gene strabismus regulates convergent extension movements in Xenopus.

Darken RS , Scola AM , Rakeman AS , Das G , Mlodzik M , Wilson PA .

The signaling mechanisms that specify, guide and coordinate cell behavior during embryonic morphogenesis are poorly understood. We report that a Xenopus homolog of the Drosophila planar cell polarity gene strabismus (stbm) participates in the regulation of convergent extension, a critical morphogenetic process required for the elongation of dorsal structures in vertebrate embryos. Overexpression of Xstbm, which is expressed broadly in early development and subsequently in the nervous system, causes severely shortened trunk structures; a similar phenotype results from inhibiting Xstbm translation using a morpholino antisense oligo. Experiments with Keller explants further demonstrate that Xstbm can regulate convergent extension in both dorsal mesoderm and neural tissue. The specification of dorsal tissues is not affected. The Xstbm phenotype resembles those obtained with several other molecules with roles in planar polarity signaling, including Dishevelled and Frizzled-7 and -8. Unlike these proteins, however, Stbm has little effect on conventional Wnt/beta-catenin signaling in either frog or fly assays. Thus our results strongly support the emerging hypothesis that a vertebrate analog of the planar polarity pathway governs convergent extension movements.

PubMed ID: 11867525
PMC ID: PMC125882
Article link: EMBO J
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: dvl2 vangl2
Morpholinos: vangl2 MO2

References [+] :
Adler, The genetic control of tissue polarity in Drosophila. 1995, Pubmed