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Mol Cell. February 1, 2002; 9 (2): 213-24.

CtBP, an unconventional transcriptional corepressor in development and oncogenesis.

Chinnadurai G .

CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.

PubMed ID: 11864595
Article link: Mol Cell.
Grant support: CA-84941 NCI NIH HHS

Genes referenced: ctbp2

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