CtBP, an unconventional transcriptional corepressor in development and oncogenesis.
CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.
PubMed ID: 11864595
Article link: Mol Cell.
Grant support: CA-84941 NCI NIH HHS
Genes referenced: ctbp2