Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Genes Dev
2002 Feb 15;164:421-6. doi: 10.1101/gad.219202.
Show Gene links
Show Anatomy links
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb budmesenchyme prior to SHH signaling.
te Welscher P
,
Fernandez-Teran M
,
Ros MA
,
Zeller R
.
???displayArticle.abstract???
The bHLH transcription factor dHAND is required for establishment of SHH signaling by the limb bud organizer in posteriormesenchyme, a step crucial to development of vertebrate paired appendages. We show that the transcriptional repressor GLI3 restricts dHAND expression to posteriormesenchyme prior to activation of SHH signaling in mouse limb buds. dHAND, in turn, excludes anterior genes such as Gli3 and Alx4 from posteriormesenchyme. Furthermore, genetic interaction of GLI3 and dHAND directs establishment of the SHH/FGF signaling feedback loop by restricting the BMP antagonist GREMLIN posteriorly. These interactions polarize the nascent limb bud mesenchyme prior to SHH signaling.
???displayArticle.pubmedLink???
11850405
???displayArticle.pmcLink???PMC155343 ???displayArticle.link???Genes Dev
Büscher,
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.
1997, Pubmed,
Xenbase
Büscher,
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.
1997,
Pubmed
,
Xenbase
Charité,
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.
2000,
Pubmed
Charité,
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures.
1994,
Pubmed
Chiang,
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
2001,
Pubmed
Cohn,
Developmental biology. Giving limbs a hand.
2000,
Pubmed
Fernandez-Teran,
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.
2000,
Pubmed
Firulli,
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.
2000,
Pubmed
HAMBURGER,
A series of normal stages in the development of the chick embryo.
1951,
Pubmed
Haramis,
The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation.
1995,
Pubmed
Hui,
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.
1993,
Pubmed
Johnson,
Molecular models for vertebrate limb development.
1997,
Pubmed
Kraus,
Some distal limb structures develop in mice lacking Sonic hedgehog signaling.
2001,
Pubmed
Lu,
Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation.
1997,
Pubmed
Marigo,
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.
1996,
Pubmed
,
Xenbase
Masuya,
Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse.
1997,
Pubmed
,
Xenbase
Masuya,
A duplicated zone of polarizing activity in polydactylous mouse mutants.
1995,
Pubmed
Qu,
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.
1997,
Pubmed
Schimmang,
Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).
1992,
Pubmed
Srivastava,
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.
1997,
Pubmed
St-Jacques,
Sonic hedgehog signaling is essential for hair development.
1998,
Pubmed
Sun,
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.
2000,
Pubmed
Takahashi,
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development.
1998,
Pubmed
,
Xenbase
Tanaka,
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly.
2000,
Pubmed
Wang,
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
2000,
Pubmed
,
Xenbase
Yelon,
The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development.
2000,
Pubmed
Zúñiga,
Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.
1999,
Pubmed
,
Xenbase
Zúñiga,
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.
1999,
Pubmed
,
Xenbase
van den Akker,
Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes.
1999,
Pubmed
van den Akker,
Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes.
2001,
Pubmed
