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XB-ART-8084
Dev Cell November 1, 2001; 1 (5): 655-65.

Neural and head induction by insulin-like growth factor signals.



Abstract
Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.

PubMed ID: 11709186
Article link: Dev Cell
Grant support: [+]
Genes referenced: ag1 chrd.1 hoxd1 igf2 igfbp5 ins otx2 rax six3 tbx2


Article Images: [+] show captions


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