Nodal signaling in early vertebrate embryos: themes and variations.
The nodal family of TGFbeta-related ligands have emerged as critical regulators of early vertebrate embryogenesis. Recent studies in mice, fish, and frogs of nodals and their intracellular transducers allow a comparison of how this signaling pathway is used in the patterning of early embryos of these different vertebrates.
PubMed ID: 11709181
Article link: Dev Cell.
Genes referenced: nodal tgfb1