XB-ART-8322Mech Dev October 1, 2001; 108 (1-2): 3-12.
The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions.
One major conclusion of studies in Developmental Biology during the last two decades is that, despite profound anatomical differences, the building of vertebrate and arthropod bodies relies on the same fundamental molecular networks, including conserved cell signalling and transcription-regulatory cascades. Rodent Early B-Cell Factor/Olfactory-1 and Drosophila Collier belong to a recently defined, novel family of transcription factors, the Collier/Olf1/EBF (COE) proteins which have a unique DNA-binding domain. Early investigations revealed that, despite their high degree of sequence identity, the different vertebrate and invertebrate COE proteins play a variety of developmental roles. We review here the current evidence for this diversity of COE functions, including in the specification and differentiation of various neuronal populations. We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions.
PubMed ID: 11578857
Article link: Mech Dev
Genes referenced: dll1 ebf1 ebf2 ebf3 neurod1 neurog1 notch1