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XB-ART-8366
FEBS Lett 2001 Sep 14;5052:233-9. doi: 10.1016/s0014-5793(01)02832-0.
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A plant Shaker-like K+ channel switches between two distinct gating modes resulting in either inward-rectifying or "leak" current.

Dreyer I , Michard E , Lacombe B , Thibaud JB .


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Among the Shaker-like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous "leak-like" and time-dependent hyperpolarisation-activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole-cell and single-channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post-translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state.

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Species referenced: Xenopus
Genes referenced: akt2 kcnk2