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XB-ART-8479
Curr Opin Genet Dev October 1, 2001; 11 (5): 533-40.

TGF-beta signalling pathways in early Xenopus development.



Abstract
Many different ligands of the TGF-beta superfamily signal in the early Xenopus embryo and are required for the specification and patterning of the three germ layers as well as for gastrulation. Recent advances in the field are helping us understand how ligand activity is regulated both spatially and temporally, the mechanism by which the signals are transduced to the nucleus and how essentially the same signalling pathway can activate completely different sets of genes in different regions of the embryo.

PubMed ID: 11532395
Article link: Curr Opin Genet Dev


Species referenced: Xenopus laevis
Genes referenced: bambi bmp2 bmp4 bmp7.1 bmpr1a cer1 chrd.1 ctnnb1 fgf4 foxh1 gdf1 mixer nodal1 nodal5.2 nodal6 smad1 smad2 smad3 smad4.1 smad6 smad6.2 smad7 smurf1 tgfb1 twsg1 vegt ventx2.2 zfyve9


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