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XB-ART-859
Proc Natl Acad Sci U S A January 17, 2006; 103 (3): 614-9.

Xbves is a regulator of epithelial movement during early Xenopus laevis development.

Ripley AN , Osler ME , Wright CV , Bader D .


Abstract
Bves/pop1a is a unique, highly conserved integral membrane protein expressed in embryonic epithelia and striated muscle. Although studies have proposed a role in epithelial morphogenesis, the function of Bves/pop1a in development is completely unknown. Here we show that Xenopus laevis Bves (Xbves) RNA and protein are expressed in epithelia of the early embryo. Transfection of Xbves into nonadherent mouse L cells confers cell/cell adhesion. Global inhibition of Xbves function by morpholino injection into two-cell embryos arrests development at gastrulation by deregulating the epithelial movements of epiboly and involution. Clonal inhibition of Xbves activity within the A1 blastomere and its derivatives completely randomizes movement of its progeny within otherwise normally differentiating embryos. These data demonstrate that Bves/pop1a proteins play a critical role in epithelial morphogenesis and, specifically, in the cell movements essential for epithelial rearrangements that occur during X. laevis development.

PubMed ID: 16407138
PMC ID: PMC1334639
Article link: Proc Natl Acad Sci U S A
Grant support: [+]
Genes referenced: bves
Antibodies: Bves Ab1 Bves Ab2
Morpholinos: bves MO1


Article Images: [+] show captions
References [+] :
Andrée, Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. 2000, Pubmed


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