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EMBO Rep
2001 Aug 01;28:727-35. doi: 10.1093/embo-reports/kve152.
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Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo.
Kusakabe M
,
Masuyama N
,
Hanafusa H
,
Nishida E
.
???displayArticle.abstract??? FRS2 has been identified in mammalian cells as a protein that is tyrosine phosphorylated and binds to Grb2 and Shp2 in response to fibroblast growth factor (FGF) or nerve growth factor (NGF) stimulation. But neither its existence in other vertebrate classes or invertebrates nor its function during embryonic development has been defined. Here we have identified and characterized a Xenopus homolog of FRS2 (xFRS2). xFRS2 is tyrosine phosphorylated in early embryos, and overexpression of an unphosphorylatable form of xFRS2 interferes with FGF-dependent mesoderm formation. The Src family kinase Laloo, which was shown to function in FGF signaling during early Xenopus development, binds to xFRS2 and promotes tyrosine phosphorylation of xFRS2. Moreover, xFRS2 and Laloo are shown to bind to Xenopus FGF receptor 1. These results suggest that xFRS2 plays an important role in FGF signaling in cooperation with Laloo during embryonic development.
Amaya,
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
1991, Pubmed,
Xenbase
Amaya,
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Basilico,
The FGF family of growth factors and oncogenes.
1992,
Pubmed
Cross,
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.
1984,
Pubmed
Dhalluin,
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.
2000,
Pubmed
Gotoh,
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
1995,
Pubmed
,
Xenbase
Hadari,
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
1998,
Pubmed
Hanafusa,
The TGF-beta family member derrière is involved in regulation of the establishment of left-right asymmetry.
2000,
Pubmed
,
Xenbase
Hudson,
Xsox17alpha and -beta mediate endoderm formation in Xenopus.
1997,
Pubmed
,
Xenbase
Isaacs,
New perspectives on the role of the fibroblast growth factor family in amphibian development.
1997,
Pubmed
,
Xenbase
Kouhara,
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
1997,
Pubmed
LaBonne,
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development.
1995,
Pubmed
,
Xenbase
MacNicol,
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF.
1993,
Pubmed
,
Xenbase
Masuyama,
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.
1999,
Pubmed
,
Xenbase
Mohammadi,
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
1996,
Pubmed
Moriguchi,
Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates.
1999,
Pubmed
,
Xenbase
Olayioye,
ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.
1999,
Pubmed
Ong,
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
2000,
Pubmed
Ong,
Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2.
1996,
Pubmed
Ong,
SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells.
1997,
Pubmed
Rabin,
SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells.
1993,
Pubmed
Shibuya,
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
1998,
Pubmed
,
Xenbase
Slack,
The role of fibroblast growth factors in early Xenopus development.
1996,
Pubmed
,
Xenbase
Tang,
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development.
1995,
Pubmed
,
Xenbase
Thomas,
Cellular functions regulated by Src family kinases.
1997,
Pubmed
Umbhauer,
Mesoderm induction in Xenopus caused by activation of MAP kinase.
1995,
Pubmed
,
Xenbase
Wang,
Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.
1996,
Pubmed
Weinstein,
FGF-mediated mesoderm induction involves the Src-family kinase Laloo.
1998,
Pubmed
,
Xenbase
Weinstein,
Src family kinase function during early Xenopus development.
2001,
Pubmed
,
Xenbase
Whitman,
Involvement of p21ras in Xenopus mesoderm induction.
1992,
Pubmed
,
Xenbase
Xu,
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
1998,
Pubmed
