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XB-ART-8698
Int J Dev Biol June 1, 2001; 45 (4): 681-4.

Differential regulation of Dlx gene expression by a BMP morphogenetic gradient.



Abstract
Three members of the vertebrate Distal-less gene family, Dlx3, 5 and 6, are transcribed in early gastrula embryos of Xenopus laevis. This expression is confined to ectoderm and is excluded from the presumptive neural plate region. Expression of all three genes is dependent upon BMP signaling, with significant differences in how the three genes respond to the BMP antagonist chordin. This correlates with the different expression domain boundaries in vivo for Dlx3 compared to Dlx5 and 6, suggesting that BMP signal attenuation could be the primary factor in determining these different patterns in the gastrula ectoderm.

PubMed ID: 11461005
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: chrd.1 dlx3 dlx5 dlx6 krt12.4 zic3


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