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XB-ART-870
Dev Dyn March 1, 2006; 235 (3): 802-10.

Role of X-Delta-2 in the early neural development of Xenopus laevis.



Abstract
The Drosophila Delta gene and its vertebrate homologues are ligands for the Notch receptor and are involved in a variety of developmental processes, including neurogenesis, boundary formation, and axon guidance. This study deals with the ectodermal expression and function of X-Delta-2 during early Xenopus laevis development. X-Delta-2 is expressed, from early neurula stages on, throughout the central nervous system (CNS; forebrain, eyes, midbrain, hindbrain, and spinal cord) and in the majority of the cranial placodes. Loss of function experiments using a morpholino knockdown approach revealed that X-Delta-2 is necessary for hindbrain segmentation and the correct specification of the anterior CNS. X-Delta-2 also seems to be important in the determination of the size of the eyes. Furthermore, our results suggest that X-Delta-2 is involved in the migration of the cranial placodes cells, as well the migration of the cranial neural crest cells.

PubMed ID: 16397897
Article link: Dev Dyn

Genes referenced: dlc dll1 dll4 dlx2 egr2 emx2 en2 gbx2.1 hoxb3 myod1 neurog2 nkx2-1 notch1 nrp1 pax6 snai1 snai2 tubb2b
Morpholinos: dlc MO2


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