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XB-ART-8778
Cell. June 29, 2001; 105 (7): 851-62.

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.

Wang D , Chang PS , Wang Z , Sutherland L , Richardson JA , Small E , Krieg PA , Olson EN .


Abstract
Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-inducible genes. Because SRF is not muscle specific, it has been postulated to activate muscle genes by recruiting myogenic accessory factors. Using a bioinformatics-based screen for unknown cardiac-specific genes, we identified a novel and highly potent transcription factor, named myocardin, that is expressed in cardiac and smooth muscle cells. Myocardin belongs to the SAP domain family of nuclear proteins and activates cardiac muscle promoters by associating with SRF. Expression of a dominant negative mutant of myocardin in Xenopus embryos interferes with myocardial cell differentiation. Myocardin is the founding member of a class of muscle transcription factors and provides a mechanism whereby SRF can convey myogenic activity to cardiac muscle genes.

PubMed ID: 11439182
Article link: Cell.
Grant support: HL63926 NHLBI NIH HHS , HL63926 NHLBI NIH HHS , HL63926 NHLBI NIH HHS , HL63926 NHLBI NIH HHS , HL63926 NHLBI NIH HHS , HL63926 NHLBI NIH HHS

Genes referenced: apcs myocd nkx2-5 srf
Antibodies referenced:
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