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Nat Rev Mol Cell Biol July 1, 2001; 2 (7): 521-9.

Translational control by CPEB: a means to the end.

Mendez R , Richter JD .

The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB--a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?

PubMed ID: 11433366
Article link: Nat Rev Mol Cell Biol

Species referenced: Xenopus
Genes referenced: cpeb1