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XB-ART-8791
Nat Cell Biol July 1, 2001; 3 (7): 643-9.

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.

Lee MJ , Gergely F , Jeffers K , Peak-Chew SY , Raff JW .


Abstract
The XMAP215/ch-TOG/Msps family of microtubule-associated proteins (MAPs) promote microtubule growth in vitro and are concentrated at centrosomes in vivo. We show here that Msps (mini-spindles protein) interacts with the centrosomal protein D-TACC, and that this interaction strongly influences microtubule behaviour in Drosophila embryos. If D-TACC levels are reduced, Msps does not concentrate at the centrosomes efficiently and the centrosomal microtubules appear to be destabilized. If D-TACC levels are increased, both D-TACC and Msps accumulate around the centrosomes/spindle poles, and the centrosomal microtubules appear to be stabilized. We show that the interaction between D-TACC and Msps is evolutionarily conserved. We propose that D-TACC and Msps normally cooperate to stabilize centrosomal microtubules by binding to their minus ends and binding to their plus ends as they grow out from the centrosome.

PubMed ID: 11433296
Article link: Nat Cell Biol

Genes referenced: ckap5 tmprss13



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