XB-ART-8792
Nat Cell Biol
July 1, 2001;
3
(7):
628-36.
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Abstract
Wnt signalling regulates beta-catenin-dependent developmental processes through the Dishevelled protein (Dsh). Dsh regulates two distinct pathways, one mediated by beta-catenin and the other by Jun kinase (JNK). We have purified a Dsh-associated kinase from Drosophila that encodes a homologue of Caenorhabditis elegans PAR-1, a known determinant of polarity during asymmetric cell divisions. Treating cells with Wnt increases endogenous PAR-1 activity coincident with Dsh phosphorylation. PAR-1 potentiates Wnt activation of the beta-catenin pathway but blocks the JNK pathway. Suppressing endogenous PAR-1 function inhibits Wnt signalling through beta-catenin in mammalian cells, and Xenopus and Drosophila embryos. PAR-1 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that PAR-1, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways.
PubMed ID: 11433294
Article link: Nat Cell Biol
Grant support:
Species referenced: Xenopus laevis
Genes referenced: dvl2 jun mapk8 mark2 mark3
References :
Depraetere,
PAR-1 helps Wnt to get rid of JNK.
2001, Pubmed