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Mech Dev May 1, 2001; 103 (1-2): 133-6.

Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye.

Sumanas S , Ekker SC .

We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.

PubMed ID: 11335120
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: fzd5 prl.1 prl.2 tbx2

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