XB-ART-921FEBS Lett January 9, 2006; 580 (1): 239-44.
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium.
The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.
PubMed ID: 16364313
Article link: FEBS Lett
Genes referenced: panx1