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XB-ART-9227
Mol Biol Cell April 1, 2001; 12 (4): 1103-16.

Changes in organization of the endoplasmic reticulum during Xenopus oocyte maturation and activation.

Terasaki M , Runft LL , Hand AR .


Abstract
The organization of the endoplasmic reticulum (ER) in the cortex of Xenopus oocytes was investigated during maturation and activation using a green fluorescent protein chimera, immunofluorescence, and electron microscopy. Dense clusters of ER developed on the vegetal side (the side opposite the meiotic spindle) during maturation. Small clusters appeared transiently at the time of nuclear envelope breakdown, disappeared at the time of first polar body formation, and then reappeared as larger clusters in mature eggs. The appearance of the large ER clusters was correlated with an increase in releasability of Ca(2+) by IP(3). The clusters dispersed during the Ca(2+) wave at activation. Possible relationships of ER structure and Ca(2+) regulation are discussed.

PubMed ID: 11294910
PMC ID: PMC32290
Article link: Mol Biol Cell
Grant support: [+]

References [+] :
Campanella, Ultrastructural observations on cortical endoplasmic reticulum and on residual cortical granules in the egg of Xenopus laevis. 1977, Pubmed, Xenbase


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