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Int J Dev Biol January 1, 2001; 45 (1): 219-24.

Making mesoderm--upstream and downstream of Xbra.

The mesoderm of the amphibian embryo is formed through an inductive interaction in which cells of the vegetal hemisphere of the embryo act on overlying equatorial cells. My laboratory is studying the Brachyury gene, which plays a key role in this interaction, being both necessary and sufficient for normal mesoderm formation. In this article I describe our attempts to understand how Xenopus Brachyury (Xbra) is activated in the right cells at the right time, and then to understand how Xbra exerts its effects.

PubMed ID: 11291849
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: 1a11 bix1.1 bix1.2 bix1.3 bix2 btg1 ctnnb1 dvl2 egr1 gdf3 gsc gsk3a inhba mapk8 mix1 mixer rac1 rhoa tbxt tcf3 vegt wnt11b wnt8a zeb2

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