Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-9315
Cell Physiol Biochem January 1, 2001; 11 (1): 55-60.
Show Gene links Show Anatomy links

Determination of protein-protein interactions of ICIn by the yeast two-hybrid system.

Schmarda A , Fresser F , Gschwentner M , Fürst J , Ritter M , Lang F , Baier G , Paulmichl M .


Abstract
ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B''.

PubMed ID: 11275683
Article link: Cell Physiol Biochem


Species referenced: Xenopus laevis
Genes referenced: clns1a snrpd2