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XB-ART-934
Org Biomol Chem 2006 Jan 07;41:155-64. doi: 10.1039/b514273c.
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Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis.

Domínguez M , Alvarez R , Borràs E , Farrés J , Parés X , de Lera AR .


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(R)-all-trans-3-hydroxyretinal 1, (S)-all-trans-4-hydroxyretinal and (R)-all-trans-4-hydroxyretinal have been synthesized stereoselectively by Horner-Wadsworth-Emmons and Stille cross-coupling as bond-forming reactions. The CBS method of ketone reduction was used in the enantioface-differentiation step to provide the precursors for the synthesis of the 4-hydroxyretinal enantiomers. The kinetic constants of Xenopus laevis ADH8 with these retinoids have been determined.

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Species referenced: Xenopus laevis
Genes referenced: adhfe1