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Localization of the extracellular end of the voltage sensor S4 in a potassium channel.
Elinder F
,
Arhem P
,
Larsson HP
.
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The opening and closing of the pore of voltage-gated ion channels is the basis for the nervous impulse. These conformational changes are triggered by the movement of an intrinsic voltage sensor, the fourth transmembrane segment, S4. The central problem of how the movement of S4 is coupled to channel opening and where S4 is located in relation to the pore is still unsolved. Here, we estimate the position of the extracellular end of S4 in the Shaker potassium channel by analyzing the electrostatic effect of introduced charges in the pore-forming motif (S5-S6). We also present a three-dimensional model for all transmembrane segments. Knowledge of this structure is essential for the attempts to understand how voltage opens these channels.
Aggarwal,
Contribution of the S4 segment to gating charge in the Shaker K+ channel.
1996, Pubmed,
Xenbase
Aggarwal,
Contribution of the S4 segment to gating charge in the Shaker K+ channel.
1996,
Pubmed
,
Xenbase
Baker,
Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating.
1998,
Pubmed
Catterall,
Molecular properties of voltage-sensitive sodium channels.
1986,
Pubmed
Cha,
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy.
1999,
Pubmed
Doyle,
The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
1998,
Pubmed
Durell,
Structural models of the transmembrane region of voltage-gated and other K+ channels in open, closed, and inactivated conformations.
1998,
Pubmed
Elinder,
The functional surface charge density of a fast K channel in the myelinated axon of Xenopus laevis.
1998,
Pubmed
,
Xenbase
Elinder,
Divalent cation effects on the Shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density.
1998,
Pubmed
,
Xenbase
Elinder,
Role of individual surface charges of voltage-gated K channels.
1999,
Pubmed
Glauner,
Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel.
1999,
Pubmed
,
Xenbase
Gulbis,
Structure of a voltage-dependent K+ channel beta subunit.
1999,
Pubmed
Hong,
The lipid-protein interface of a Shaker K(+) channel.
2000,
Pubmed
,
Xenbase
Horn,
A new twist in the saga of charge movement in voltage-dependent ion channels.
2000,
Pubmed
Hoshi,
Biophysical and molecular mechanisms of Shaker potassium channel inactivation.
1990,
Pubmed
,
Xenbase
Kamb,
Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.
1987,
Pubmed
Keynes,
The screw-helical voltage gating of ion channels.
1999,
Pubmed
Larsson,
Transmembrane movement of the shaker K+ channel S4.
1996,
Pubmed
,
Xenbase
Larsson,
A conserved glutamate is important for slow inactivation in K+ channels.
2000,
Pubmed
,
Xenbase
Li-Smerin,
A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel.
2000,
Pubmed
,
Xenbase
Mannuzzu,
Direct physical measure of conformational rearrangement underlying potassium channel gating.
1996,
Pubmed
,
Xenbase
McLaughlin,
The electrostatic properties of membranes.
1989,
Pubmed
Peitzsch,
Calculations of the electrostatic potential adjacent to model phospholipid bilayers.
1995,
Pubmed
Seoh,
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel.
1996,
Pubmed
,
Xenbase
Tiwari-Woodruff,
Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits.
1997,
Pubmed
,
Xenbase
Tiwari-Woodruff,
Voltage-dependent structural interactions in the Shaker K(+) channel.
2000,
Pubmed
,
Xenbase
Yang,
Probing the outer vestibule of a sodium channel voltage sensor.
1997,
Pubmed
Yellen,
The moving parts of voltage-gated ion channels.
1998,
Pubmed
Yusaf,
Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel.
1996,
Pubmed
,
Xenbase
