Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO Rep
2001 Feb 01;22:113-8. doi: 10.1093/embo-reports/kve022.
Show Gene links
Show Anatomy links
The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition.
Akhtar A
,
Becker PB
.
???displayArticle.abstract???
Site-specific acetylation of histone H4 by MOF is central to establishing the hyperactive male X chromosome in Drosophila. MOF belongs to the MYST family of histone acetyltransferases (HATs) characterized by an unusual C2HC-type zinc finger close to their HAT domains. The function of these rare zinc fingers is unknown. We found that this domain is essential for HAT activity, in addition to the established catalytic domain. MOF uses its zinc finger to contact the globular part of the nucleosome as well as the histone H4 N-terminal tail substrate. Point mutations that leave the zinc-finger structure intact nevertheless abolish its interaction with the nucleosome. Our data document a novel role of the C2HC-type finger in nucleosome binding and HAT activity.
Akhtar,
Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.
2000, Pubmed
Akhtar,
Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.
2000,
Pubmed
Akhtar,
Chromodomains are protein-RNA interaction modules.
2000,
Pubmed
Arrizabalaga,
A selective screen reveals discrete functional domains in Drosophila Nanos.
1999,
Pubmed
Baker,
Dosage compensation in Drosophila.
1994,
Pubmed
Brown,
The many HATs of transcription coactivators.
2000,
Pubmed
Candau,
Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo.
1997,
Pubmed
Clapier,
Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI.
2001,
Pubmed
,
Xenbase
Godde,
The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA.
1995,
Pubmed
,
Xenbase
Gorelick,
Characterization of the block in replication of nucleocapsid protein zinc finger mutants from moloney murine leukemia virus.
1999,
Pubmed
Grant,
Histone acetyltransferase complexes.
1999,
Pubmed
Gu,
Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.
2000,
Pubmed
Hammarström,
Solution structure of a naturally-occurring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit.
1996,
Pubmed
Hilfiker,
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.
1997,
Pubmed
Ivanova,
The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast.
1998,
Pubmed
Lucchesi,
Dosage compensation in flies and worms: the ups and downs of X-chromosome regulation.
1998,
Pubmed
Lucchesi,
Dosage compensation: roX marks the spot.
1999,
Pubmed
Luger,
Characterization of nucleosome core particles containing histone proteins made in bacteria.
1997,
Pubmed
,
Xenbase
Meller,
Ordered assembly of roX RNAs into MSL complexes on the dosage-compensated X chromosome in Drosophila.
2000,
Pubmed
Paro,
The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.
1991,
Pubmed
Pedone,
The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding.
1996,
Pubmed
Schmeichel,
Molecular dissection of a LIM domain.
1997,
Pubmed
Schwabe,
Zinc mining for protein domains.
1994,
Pubmed
Smith,
The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation.
2000,
Pubmed
Strahl,
The language of covalent histone modifications.
2000,
Pubmed
Stuckenholz,
Guilt by association: non-coding RNAs, chromosome-specific proteins and dosage compensation in Drosophila.
1999,
Pubmed
Takechi,
Sas3 is a histone acetyltransferase and requires a zinc finger motif.
1999,
Pubmed
Urbaneja,
Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function.
1999,
Pubmed
