Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-9387
Nat Rev Genet. December 1, 2000; 1 (3): 171-81.

The establishment of Spemann''s organizer and patterning of the vertebrate embryo.



Abstract
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or ''back-to-belly'', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann''s organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.

PubMed ID: 11252746
PMC ID: PMC2291143
Article link: Nat Rev Genet.
Grant support: R37 HD021502-14 NICHD NIH HHS

Genes referenced:
Antibodies referenced:

My Xenbase: [ Log-in / Register ]
version: [3.2.2]


Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556