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Neuron February 1, 2001; 29 (2): 441-52.

Electrical activity modulates growth cone guidance by diffusible factors.

Ming G , Henley J , Tessier-Lavigne M , Song H , Poo M .

Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca(2+) during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca(2+) and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

PubMed ID: 11239434
Article link: Neuron
Grant support: [+]

References :
Harris, Stimulating new turns. 2001, Pubmed, Xenbase

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