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XB-ART-9471
Mech Dev 2001 Mar 01;1011-2:105-10. doi: 10.1016/s0925-4773(00)00559-1.
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The circadian gene Clock is restricted to the anterior neural plate early in development and is regulated by the neural inducer noggin and the transcription factor Otx2.

Green CB , Durston AJ , Morgan R .


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The circadian cycle is a simple, universal molecular mechanism for imposing cyclical control on cellular processes. Here we have examined the regulation of one of the key circadian genes, Clock, in early Xenopus development. We find that the expression of Clock is dependent on developmental stage, not on time per se, and is mostly restricted to the anterior neural plate. It's expression can be induced by the secreted polypeptide noggin, and subsequently upregulated by Otx2, a transcription factor required for the determination of anterior fate.

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Species referenced: Xenopus
Genes referenced: clock nog otx2


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