Cell cycle. License withheld--geminin blocks DNA replication.
A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).
PubMed ID: 11188727
Article link: Science.
Genes referenced: cdt1 gmnn