Science 2000 Oct 27;2905492:725-6. doi: 10.1126/science.290.5492.725.

Signal transduction. N-WASP regulation--the sting in the tail.

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Signaling proteins can be regulated by their interactions with other proteins and phospholipids. As Fawcett and Pawson discuss in their Perspective, activation of the N-WASP protein (which coordinates formation of actin filaments) is far more complex, depending on the interaction of N-WASP with both a protein and a phospholipid. The authors explain new results (Prehoda et al.) demonstrating that cooperative binding of the phospholipid PIP2 and the small GTPase Cdc42 to N-WASP results in its activation. The Arp2/3 complex is then able to bind to N-WASP and to proceed with its job of initiating the assembly of actin monomers into actin filaments.

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Species referenced: Xenopus
Genes referenced: actl6a cdc42 tbx2 was wasl