Distinct expression patterns for two Xenopus Bar homeobox genes.
The BarH1 and BarH2 homeobox genes are coexpressed in cells of the fly retina and in the central and peripheral nervous systems. The fly Bar genes are required for normal development of the eye and external sensory organs. In Xenopus we have identified two distinct vertebrate Bar-related homeobox genes, XBH1 and XBH2. XBH1 is highly related in sequence and expression pattern to a mammalian gene, MBH1, suggesting that they are orthologues. XBH2 has not previously been identified but is clearly related to the Drosophila Bar genes. During early Xenopus embryogenesis XBH1 and XBH2 are expressed in overlapping regions of the central nervous system. XBH1, but not XBH2, is expressed in the developing retina. By comparing the expression of XBH1 with that of hermes, a marker of differentiated retinal ganglion cells, we show that XBH1 is expressed in retinal ganglion cells during the differentiation process, but is down-regulated as cells become terminally differentiated.
PubMed ID: 11180814
Article link: Dev Genes Evol.
Grant support: HL52746 NHLBI NIH HHS , HL52746 NHLBI NIH HHS , HL52746 NHLBI NIH HHS , HL52746 NHLBI NIH HHS , HL52746 NHLBI NIH HHS , HL52746 NHLBI NIH HHS
Genes referenced: barhl1 barhl2 rbpms2