XB-ART-9578Dev Genes Evol. November 1, 2000; 210 (11): 579-81.
Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.
Nkx-2.1 is a member of the vertebrate Nkx family of homeobox genes; it was originally identified as a tissue-specific regulator of thyroglobulin and thyroperoxidase gene transcription. Here we report on the embryonic expression of Xnkx-2.1, which is expressed in the presumptive forebrain from early neurulation onwards. In tadpole stage embryos Xnkx-2.1 transcripts are primarily detected in ventral forebrain, lung buds and thyroid anlage. Therefore, Xnkx-2.1 may be part of the genetic network that controls the early development of these organs.
PubMed ID: 11180810
Article link: Dev Genes Evol.
Genes referenced: nkx2-1 nkx2-2 nkx2-3 nkx2-4 nkx2-5 nkx2-6