Dev Dyn 2001 Feb 01;2202:163-8. doi: 10.1002/1097-0177(2000)9999:9999<1::AID-DVDY1098>3.0.CO;2-5.

Src family kinase function during early Xenopus development.

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The Src family kinase Laloo functions downstream of the fibroblast growth factor (FGF) receptor, as a component of a signaling pathway required for mesoderm formation. In this study, we first show that Laloo expression can mimic FGF function in a distinct context, suggesting that the Src-related kinases are general transducers of FGF signaling during development. We then characterize the role of the SH-PTP2 phosphatase, and of bone morphogenetic protein (BMP)-pathway signaling, in mesoderm induction by Laloo. Finally, we demonstrate that the mesoderm-inducing activity of the Src family kinases is not limited to Laloo, indicating a degree of functional overlap between members of this gene family during early vertebrate development.

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Species referenced: Xenopus
Genes referenced: hck